Argentine striker Franco Di Santo (FDS) began his national team career at the u-20. He had a decent return in front of goal for the Argentina u-20 team. Franco Di Santo scored five goals in 25 appearances for his country at u-20 level.

Franco Di Santo played his first game for the u-20s during a friendly game against France and he was able to mark his debut with a goal. The striker was part of the Argentina squad that finished second behind arch rivals Brazil at the 2007 edition of the South American Youth Championship in Paraguay. Brazil won the tournament with a two-point advantage over Franco Di Santo and his Argentina team.

An invitation was extended to Franco Di Santo for him to be part of the Argentina u-20 squad to the 2009 edition of the South American Youth Championship in Venezuela, but his participation was blocked by Chelsea. The Premier League outfit had an injury crisis at the time and they prevented the attacker from honouring the invitation as a result. Franco Di Santo played for the Argentina u-20 team over a three-year period from 2006 to 2009.

Franco Di Santo was called up to the Argentina senior team by the late Alejandro Sabella on October 31, 2012. It was his first invitation to the senior setup as far as the Argentine national team is concerned. He was invited to the senior squad ahead of the international friendly clash with Saudi Arabia on November 14, 2012. He was given a shock call-up to the Argentina camp as part of a 30-man provisional squad in May 2014 ahead of the 2014 FIFA World Cup tournament in Brazil. According to BBC Sport, Franco Di Santo was a surprise inclusion in the provisional list. Later in May 2014, he was one of the four players cut from the second 26-man provisional squad.